編輯日期：2023-02-27作者：燕陽醫療
近日，由中國醫科大學附屬第一醫院齊瑞群，陳洪鐸，李珊珊，高興華等多位教授根據臨床試驗撰寫的英文文獻：“ Clearance of multiple cutaneous warts by targeting a single lesion: a randomized comparative evaluation of mild local hyperthermia versus cryotherapy”（通過單一病灶清除多發性皮膚疣：輕度局部熱療與冷凍治療的隨機比較評估）已在皮膚領域臨床研究最高影響力期刊-美國皮膚病學會雜志《JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY》發布。
Rui-Qun Qi，Hong-Duo Chen, Shanshan Li , Xing-Hua Gao，et al. Clearance of multiple cutaneous warts by targeting a single lesion: a randomized comparative evaluation of mild local hyperthermia versus cryotherapy. J Am Acad Dermatol. 2022 Aug 4;S0190-9622(22)02420-3. doi: 10.1016/j.jaad.2022.07.043. Online ahead of print. PMID: 35934211
影響因子高達15.487
節選自文獻：Clearance of multiple cutaneous warts by targeting a single lesion: a randomized comparative evaluation of mild local hyperthermia versus cryotherapy
該文在介紹局部溫熱治療可誘導免疫反應會啟動對含有相同人乳頭瘤病毒類型的其他非靶向或遠程病變的疣體免疫清除的基礎上，以兩個中心、時長4個月、評估盲法隨機對照試驗；借助研究成果轉化設備-紅外特定波光能溫熱治療儀，通過對多發性皮膚疣患者靶點應用局部溫熱療法或冷凍療法來評估整體清除療效為論點；再一次驗證了局部溫熱可使機體建立針對病原的免疫識別，從而達到清除疣體的療效。
注釋：
Calculations are made on intent-to-treat populations.
CI, Confidence interval; SD, standard deviation; VAS, visual analog scale.
*The rate difference and the 95% confidence interval for the difference between 2 independent arms, calculated according to the Wilson
procedure with a correction for continuity.
y Mixed types: patients with both diagnosed verruca vulgaris and plantar warts.
z t test on the VAS scores collected during treatment at day 1, week 2, and week 4, for the 2 groups of patients.
更以詳細的數據排列，對比分析了局部溫熱與冷凍療法治療尋常疣、跖疣、尖銳濕疣的臨床效果，通過對照兩種治療方式（局部溫熱&冷凍療法）的非靶向病灶和靶點病灶的清除率及其他治療副作用，總結了局部溫熱療法可單靶點治療人乳頭瘤病毒感染性皮膚疣的效果優勢與治愈率優勢，并通過了試驗中心協作為溫熱免疫誘導療法的進一步大范圍應用提供了全面的專業學術支撐。
參考文獻：
1. De Planell-Mas E, Mart??nez-Garriga B, Zalacain AJ, Vinuesa T,Vi~ nas M. Human papillomaviruses genotyping in plantar warts.J Med Virol. 2017;89(5):902-907.
2. Huo W, Gao YL, Wang HY, et al. Local hyperthermia versus cryotherapy for treatment of plantar warts: a prospective multi-centre non-randomized concurrent controlled clinicaltrial. Acta Derm Venereol. 2022;102:adv00655.
3. Jean LB, Julie VS, Lorenzo C. Dermatology. 4th ed. Elsevier; 2018.
4. Huo W, Gao XH, Sun XP, et al. Local hyperthermia at 44degrees C for the treatment of plantar warts: a randomized,patient-blinded, placebo-controlled trial. J Infect Dis. 2010;201(8):1169-1172.
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